Normothermic machine perfusion may prevent regulated cell death following renal ischemia‐reperfusion injury
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چکیده
منابع مشابه
Normothermic perfusion machine in liver transplant with cardiac death donor grafts.
The increasing difference between the number of patients in waiting lists for liver transplantation and the number of available donors has generated a great interest in the use of non-ideal organs, like grafts obtained from cardiac death donors (DCD). However, the extreme sensibility to ischemia of these livers results in a low utilization rate and a high percentage of post-transplant complicat...
متن کاملRecovery of donor hearts after circulatory death with normothermic extracorporeal machine perfusion.
OBJECTIVES A severe donor organ shortage leads to the death of a substantial number of patients who are listed for transplantation. The use of hearts from donors after circulatory death could significantly expand the donor organ pool, but due to concerns about their viability, these are currently not used for transplantation. We propose short-term ex vivo normothermic machine perfusion (MP) to ...
متن کاملEx Situ Normothermic Machine Perfusion of Donor Livers.
In contrast to conventional static cold preservation (0-4 °C), ex situ machine perfusion may provide better preservation of donor livers. Continuous perfusion of organs provides the opportunity to improve organ quality and allows ex situ viability assessment of donor livers prior to transplantation. This video article provides a step by step protocol for ex situ normothermic machine perfusion (...
متن کاملExtracorporeal Normothermic Pancreas Perfusion
Acknowledgement Contextual Statement Thesis Declaration Publication 1 Statement of Authorship Extracorporeal Machine Perfusion of the Pancreas: Technical Aspects and Its Clinical Implications – A Systematic Review of Experimental Models Publication 2 Statement of Authorship A Study of Normothermic Hemo-Perfusion of the Porcine Pancreas and Kidney Operative description with illustrations
متن کاملMechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion
Ischaemia-reperfusion injury (IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells (LSEC). Recent evidence suggests that LSEC co-ordinate and regulates the livers response to a variety of injuries. It ...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2018
ISSN: 1600-6135,1600-6143
DOI: 10.1111/ajt.15189